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2016年〜

Reconstitution in vitro of the entire cycle of the mouse female germ line.

Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K.

Nature. 2016 Oct 17. doi: 10.1038/nature20104.nature press

Production of functional oocytes from mouse pluripotent stem cells.

Hayashi K, Hikabe O, Hamazaki N, Nagamatsu G, Shimamoto S, Hamada N.

Protocol Exchange. 2016 Oct 19 (Online), doi:10.1038/protex.2016.065.pe

Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells.

Shirane K, Kurimoto K, Yabuta Y, Yamaji M, Satoh J, Ito S, Watanabe A, Hayashi K, Saitou M, Sasaki H.

Dev Cell. 2016; 39(1):87-103.

Complete in vitro generation of fertile oocytes from mouse primordial germ cells.

Morohaku K, Tanimoto R, Sasaki K, Kawahara-Miki R, Kono T, Hayashi K, Hirao Y, Obata Y.

Proc Natl Acad Sci USA. 2016;113(32):9021-9026.

Rewinding the process of mammalian extinction.

Saragusty J, Diecke S, Drukker M, Durrant B, Friedrich Ben-Nun I, Galli C, Göritz F, Hayashi K, Hermes R, Holtze S, Johnson S, Lazzari G, Loi P, Loring JF, Okita K, Renfree MB, Seet S, Voracek T, Stejskal J, Ryder OA, Hildebrandt TB.

 Zoo Biol. 2016;35(4):280-292.

2014年〜2015年

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

Kurimoto K, Yabuta Y, Hayashi K, Ohta H, Kiyonari H, Mitani T, Moritoki Y, Kohri K, Kimura H, Yamamoto T, Katou Y, Shirahige K, Saitou M.

Cell Stem Cell. 2015; 16, 517-532.

Possibilities in Germ Cell Research: An Engineering Insight.

Esfandiari F, Mashinchian O, Ashtiani MK, Ghanian MH, Hayashi K, Saei AA, Mahmoudi M, Baharvand H.

Trends Biotechnol. 2015 Dec;33(12):735-46. doi: 10.1016/j.tibtech.2015.09.004. Epub 2015 Oct 20. Review.10.

Perspectives of germ cell development in vitro in mammals.

Hayashi K,Saitou M

Anim Sci J. 2014; 85: 617-26.

Induction of Primordial Germ Cell-Like Cells from Mouse Embryonic Stem Cells by ERK Signal Inhibition.

Kimura T, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, Nakano T.

Stem Cells. 2014l Jul 3. Online. 

2013年以前

A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.

Aramaki S, Hayashi K, Kurimoto K, Ohta H, Yabuta Y, Iwanari H, Mochizuki Y, Hamakubo T, Kato Y, Shirahige K, Saitou M.

Dev Cell. 2013; 27: 516-529. 

Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming.

Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT.

Mol Cell. 2013; 52: 805-818. 

Stepwise differentiation from naïve state pluripotent stem cells to functional primordial germ cells through an epiblast-like state.

Hayashi K, Saitou M.

Methods Mol Biol. 2013; 1074: 175-183. 

Induction of the mouse germ-cell fate by transcription factors in vitro.

Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M.

Nature 2013; 501: 222-226. 

Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells.

Hayashi K and Saitou M.

Nature Protoc. 2013; 8: 1513-1524. 

PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.

Yamaji M, Ueda J, Hayashi K, Ohta H, Yabuta Y, Kurimoto K, Nakato R, Yamada Y, Shirahige K, Saitou M.

Cell Stem Cell. 2013; 12 : 368-382. 

Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice.

Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M.

Science. 2012; 338: 971-975. 

Epiblast stem cell-based system reveals reprogramming synergy of germline factors.

Gillich A, Bao S, Grabole N, Hayashi K, Trotter MW, Pasque V, Magnúsdóttir E, Surani MA.

Cell Stem Cell. 2012; 10: 425-439. 

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

Hayashi K, Ohta H, Kurimoto K, Aramaki S, Saitou M.

Cell. 2011; 146: 519-532. 

Dissecting ensemble networks in ES cell populations reveals micro-heterogeneity underlying pluripotency.

Trott J, Hayashi K, Surani A, Babu MM, Martinez-Arias.A.

Mol Biosyst. 2012; 8: 744-752. 

Antagonistic crosstalk of Wnt/-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.

Villacorte M, Suzuki K, Hayashi K, de Sousa Lopes SC, Haraguchi R, Taketo MM, Nakagata N, Yamada G.

Biochem Biophys Res Commun. 2010; 391: 1653-1657. 

Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells.

Hanina SA, Mifsud W, Down TA, Hayashi K, O’Carroll D, Lao K, Miska EA, Surani MA.

PLoS Genet. 2010; 6: e1001163. 

Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells.

Bao S, Tang F, Li X, Hayashi K, Gillich A, Lao K, Surani MA.

Nature. 2009; 461: 1292-1295. 

Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro.

Hayashi K and Surani MA.

Development. 2009; 136: 3549-3556. 

ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage.

Yeap LS, Hayashi K, Surani MA.

Epigenetics Chromatin. 2009; 2: 12 

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

Nakayama J, Yamamoto M, Hayashi K, Satoh H, Bundo K, Kubo M, Goitsuka R, Farrar MA, Kitamura D.

Blood. 2009; 113: 1483-1492. 

Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states.

Hayashi K, Chuva de Sousa Lopes SM, Tang F, Surani MA.

Cell Stem Cell. 2008; 3: 391-401. 

Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.

Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A, Hayashi K, Ogawa S, Takeda K, Tanabe K, Abe R.

J Immunol. 2008; 180: 5222-5234. 

A sensitive multiplex assay for piRNA expression.

Tang F, Hayashi K, Kaneda M, Lao K, Surani MA.

Biochem Biophys Res Commun. 2008; 369: 1190-1194. 

MicroRNA. Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis.

Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O’Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA.

PLoS ONE. 2008; 3: e1738. 

X Chromosome Activity in Mouse XX Primordial Germ Cells.

Chuva de Sousa Lopes SM, Hayashi K, Shovlin TC, Mifsud W, Surani MA, McLaren A.

PLoS Genet. 2008; 4: e30 

Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production.

Hidano S, Sasanuma H, Ohshima K, Seino K, Kumar L, Hayashi K, Hikida M, Kurosaki T, Taniguchi M, Geha RS, Kitamura D, Goitsuka R.

Int Immunol. 2008; 20: 345-352. 

Proximal visceral endoderm and extraembryonic ectoderm regulate the formation of primordial germ cell precursors.

Chuva de Sousa Lopes SM, Hayashi K, Surani MA.

BMC Dev Biol. 2007; 7: 140 

BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces κ gene rearrangement.

Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D.

Blood. 2006; 108: 2703-2711. 

The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

Tanaka S, Tsukada J, Suzuki W, Hayashi K, Tanigaki K, Tsuji M, Inoue H, Honjo T, Kubo M.

Immunity. 2006; 24: 689-701. 

Double knockout mice show BASH and PKC delta have different epistatic relationships in B cell maturation and CD40-mediated activation.

Nojima T, Hayashi K, Goitsuka R, Nakayama K, Nakayama K, Kitamura D.

Immunol Lett. 2006; 105: 48-54. 

Dual function for the adaptor MIST in IFN-gamma production by NK and CD4(+)NKT cells regulated by the Src kinase Fgr.

Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R.

Blood. 2006; 107: 3647-3655. 

A Histone H3 methyltransferase controls epigenetic events required for meiotic prophase.

Hayashi K, Yoshida K, Matsui Y.

Nature. 2005; 438: 374-378. 

Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse α2(XI) collagen promoter.

Fujimaki R, Hayashi K, Watanabe N, Yamada T, Toyama Y, Tezuka, K and Hozumi N.

J Bone Miner Metab 2005; 23: 270-273. 

Mouse epiblasts change responsiveness to BMP4 signal required for PGC formation through functions of extraembryonic ectoderm.

Okamura D, Hayashi K, Matsui Y.

Mol Reprod Dev. 2005; 70: 20-29. 

Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice.

Seki Y, Hayashi K, Itoh K, Mizugaki M, Saitou M, Matsui Y.

Dev Biol. 2005; 278: 440-458. 

Impaired Receptor Editing in the Primary B Cell Repertoire of BASH-Deficient Mice.

Hayashi K, Nojima T, Goitsuka R and Kitamura D.
J Immunol. 2004; 173: 5980-5988.

IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation.

Seki N, Miyazaki M, Suzuki W, Hayashi K, Arima K, Myburgh E, Izuhara K, Brombacher F, Kubo M.

J Immunol. 2004; 172: 6158-6166. 

BASH-deficient mice: limited primary repertoire and antibody formation, but sufficient affinity maturation and memory B cell generation, in anti-NP response.

Yamamoto M, Nojima, T, Hayashi K, Goitsuka R, Furukawa K, Azuma T, Kitamura D.
Int Immunol. 2004; 16: 1161-1171.

Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors.

Hayashi K., Yamamoto M., Nojima T., Goitsuka R., Kitamura D.

Immunity 2003; 18: 825-836. 

Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK.

Johmura S, Oh-hora M, Inabe K, Nishikawa Y, Hayashi K, Vigorito E, Kitamura D, Turner M, Shingu K, Hikida M, Kurosaki T.

Immunity 2003; 18: 777-787. 

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O’Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.

Nature Med. 2003; 9: 1047-1054. 

A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.

Matsumoto A, Seki Y, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M.

J Exp Med 2003; 197: 425-436. 

SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.

Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D.

Mech Dev. 2002; 118: 99-109. 

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.

Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M.

PNAS. 2002; 99: 13003-13008. 

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo.

Harada Y, Tokushima M, Matsumoto Y, Ogawa S, Otsuka M, Hayashi K, Weiss BD, June CH, Abe R.

J Immunol. 2001; 166: 3797-3803. 

A Pivotal Role for DNase I-Sensitive Regions 3b and/or 4 in the Induction of Somatic Hypermutation of IgH Genes.

Terauchi A, Hayashi K, Kitamura D, Kozono Y, Motoyama N, Azuma T.

J Immunol. 2001; 167: 811-820.  

A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.

Goitsuka R, Kanazashi H, Sasanuma H, Fujimura Yi, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D.

Int Immunol. 2000; 12: 573-580. 

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells.

Hayashi K, Nittono R, Okamoto N, Tsuji S, Hara Y, Goitsuka R, Kitamura D.

PNAS 2000; 97: 2755-2760.

英文総説


Perspectives of germ cell development in vitro in mammals.

Hayashi K, Saitou M.

Anim Sci J. 2014; 85: 617-26.

Switching stem cell state through programmed germ cell reprogramming.

Gillich A, Hayashi K.

Differentiation. 2011; 81: 281-291.

Generation of functional primordial germ cells from pluripotent stem cells.

Hayashi K. Saitou M.

J Mamm Ova Res. 2009; 26: 171-177.

Resetting the epigenome beyond pluripotency in the germ line.

Hayashi K and Surani MA.

Cell Stem Cell. 2009; 4: 493-498.

Germ Line, Stem Cells, and Epigenetic Reprogramming.

Surani MA, Durcova-Hills G, Hajkova P, Hayashi K, Tee WW.

Cold Spring Harb Symp Quant Biol. 2008; 73: 9-15.

Germ cell specification in mice.

Hayashi K, Chuva de Sousa Lopes SM, Surani MA.

Science. 2007; 316: 394-396. 

Genetic and epigenetic regulators of pluripotency.

Surani MA, Hayashi K, Hajkova P.

Cell 2007; 128: 747-762. 

Epigenetic regulation for the induction of meiosis.

Matsui Y, Hayashi K.

Cell Mol Life Sci. 2007; 64 : 257-262. 

Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis.

Hayashi K, Matsui Y.

Cell Cycle. 2006; 5: 615-620. 

和文総説


体外培養による多能性幹細胞からの配偶子の作製

林克彦,斎藤通紀

遺伝 2013; 67: 503-509.

ES/iPS 細胞からの機能的な卵子の作製

林克彦,斎藤通紀

実験医学 2013; 31: 563-566.

ES・iPS細胞からの機能的な始原生殖細胞の分化 

林克彦,斎藤通紀

実験医学増刊「幹細胞のメディカルサイエンス」2012; 30: 157-162.

体内および体外における始原生殖細胞の初期発生

林克彦

日本哺乳動物卵子学会誌 2009; 26: 171-177.

生殖細胞系列特異的なヒストン修飾酵素と減数分裂

林克彦, 松居靖久

蛋白質・核酸・酵素,51(5),(2006),441-445.

減数分裂の進行に必須な新規ヒストンメチル化酵素Meisetz

林克彦, 松居靖久

細胞工学 2006; 25: 48-49.

配偶子形成 生殖細胞分化におけるエピジェネティックな制御 医学のあゆみ

松居靖久, 林克彦

2006; 217: 593-598.

ヒストンメチル化酵素Meisetzによる減数分裂の制御

松居靖久, 林克彦

ブレイン・テクノニュース 2006; 115: 25-29.

減数分裂の分子基盤と異常

林克彦

大阪府立母子保健総合医療センター雑誌 2005; 20: 45-50.

マウス生殖細胞系列のエピジェネティクスと減数分裂の異常

林克彦、松居靖久

実験医学 2005; 23: 712-718.

B細胞の活性化とBASH

林克彦,後飯塚僚

臨床免疫 1999; 32: 411-416

著書


Stepwise differentiation from naïve state pluripotent stem cells to functional primordial germ cells through an epiblast-like state.

Hayashi K and Saitou M: S

Chapter: Epiblast Stem Cells- Methods and Protocols.

Method in Molecular Biology, Springer, in press

生殖系幹細胞

林克彦,斎藤通紀:

再生医療叢書「幹細胞」山中伸弥、中内啓光編集 p89-p11

学会発表等


国際学会・国際シンポジウム

Production of sperm and oocyte from pluripotent stem cells in mice

Hayashi K

Korea-Japan Biomodulation symposium , Seoul, (2013年5月)

Generation of eggs and spermatozoa from pluripotent stem cells in mice

Hayashi K

The 3rd International Congress on Controversies in Cryopreservation of Reproductive cells, Tissue and Organs.  Berlin (2013年3月)

Producing sperms and eggs from iPSC.

Hayashi K

2013 The International Conference on Preservation of Fertility in Cancer Patient, Hong Kong (2013年1月)

Generation of fertile gametes from mouse embryonic stem cells and induced pluripotent stem cells

Hayashi K, Ogushi S, Shimamoto S, Kurimoto K, Ohta H and Saitou M.

2012 EMBL symposium Germline – Immortality through Totipotency, Heidelberg (2012年10月)

Production of fertile gametes from mouse pluripotent stem cells

Hayashi K, Ogushi S and Saitou M.

SRD-NIAS The 2nd Japan-Czech Joint Symposium, Tokyo(2012年9月)

Production of fertile gametes from mouse pluripotent stem cells

Hayashi K and Saitou M.

The 58th NIBB Conference, Germline -Specification, Sex, Stem Cells, Okazaki (2012年7月)

Reconstitution of the mouse primordial germ cell specification by pluripotent stem cells

Hayashi K.

 The International Symposium on Animal Biotechnology, Nagano (2012年1月)

A model stem cell system for mouse germ cell formation and epigenetic reprogramming

Hayashi K and Surani MA.

Cold spring harbor meeting, New York (2008年10月)

Distinct roles of small RNAs in mouse primordial germ cell development and gametegenesis

Hayashi K, Haijkova P, O’Carrol, Das PP, Lopes SM, Kaneda M, Tang F, Tarakhovsky, Miska E, Surani MA

CDB symposium Kobe(2007年3月)

Expression profiling and function of microRNA in mouse primordial germ cells

Hayashi K, Haijkova P, O’Carrol, Das PP, Lopes SM, Kaneda M, Tang F, Tarakhovsky, Miska E, Surani MA.

Cold spring harbor meeting, New York (2006年10月)

A critical role of Meisetz encoding meiosis-specific histone methyltransferase in mouse gametegenesis

Hayashi K and Matsui Y.

Cold spring harbor meeting, New York (2004年10月)

国内学会・シンポジウム

Mechanism and reconstitution in vitro of germ cell specification in mice

林克彦.

第45回日本発生生物学会・第64回日本細胞生物学会合同大会シンポジウム 神戸・国際会議場(2012年5月)

多能性幹細胞から分化誘導した始原生殖細胞由来の産仔の作製

林克彦,大田浩,栗本一基,荒牧伸弥,斎藤通紀.

第104回日本繁殖生物学会大会  盛岡・県民情報交流センター(2011年9月)

多能性幹細胞から生殖細胞への分化- 発生モデルの構築と応用への基盤整備

林克彦

2010年度生殖工学会学術集会 東京・麻布大学(2010年11月)

多能性幹細胞の自己増殖と生殖細胞への分化

林克彦.

第51回日本哺乳動物卵子学会 新潟・朱鷺メッセ (2010年5月)

減数分裂時に特異的に発現するヒストンメチル化酵素Meisetzの機能解析

林克彦,松居靖久.

第27回日本分子生物学会 神戸・国際会議場( (2004年12月)

B細胞初期分化を制御するpre-BCRを介したシグナル伝達の解析

林克彦,山本睦美,野嶋卓也,北村大介.

第32回日本免疫学会総会 東京・京王プラザ (2002年12月)

マウス始原生殖細胞の発生におけるSmad1の役割

林克彦,小林隆志,入戸野亮,後飯塚僚,北村大介

第23回日本分子生物学会大会 神戸・国際会議場(2000年12月)

マウス始原生殖細胞(PGCs)の発生におけるSmad1の役割

林克彦,小林隆志,入戸野亮,後飯塚僚,北村大介

第92回日本繁殖生物学会 仙台・仙台国際センター(1999年9月)

Cre-loxP systemを用いた精巣へ導入された外来遺伝子の解析

林克彦,前原正樹,北村大介,多田昇弘,尾川昭三

第91回日本繁殖生物学会 札幌・北海道大学(1998年8月)

B細胞特異的に発現する新規シグナル分子BASH:マウスBASHの構造と発現

林克彦,岡本憲明,辻佐智代,梅田昭子,後飯塚僚,北村大介

第28回日本免疫学会総会 神戸・国際会議場(1998年12月)

研究会等

多能性幹細胞からの配偶子形成とその課題

林克彦

大阪小児先進医療研究会 大阪・大阪大学(2012年11月)

林克彦.生殖細胞の体外培養における創出と課題 第14回麻布大学生殖・発生工学セミナー東京・麻布大学 (2011年11月)

林克彦.

第14回麻布大学生殖・発生工学セミナー東京・麻布大学 (2011年11月)

iPS細胞からの始原生殖細胞と産仔の作出 精子研究会

林克彦.

東京・慶応義塾大学(2011年11月)

多能性幹細胞の自己増殖状態の変化と生殖細胞への分化

林克彦.

東京理科大学大学院特別講義 野田・東京理科大学(2011年7月)

ES/iPS細胞を用いた体外培養による始原生殖細胞分化の再構築

林克彦.

第38回幹細胞治療研究フォーラム 東京・東京大学医科学研究所(2011年6月)

胚性幹細胞の不均一性と分化能

林克彦.
第1回配偶子制御セミナー 横浜・横浜市立大学(2009年3月)

始原生殖細胞の減数分裂制御機構の解析 生殖工学研究会

林克彦,松居靖久

〜生殖細胞における発生制御の新しい試み〜 大阪・大阪厚生年金会館(2004年3月)

特許


METHOD OF INDUCING DIFFERENTIATION FROM PLURIPOTENT STEM CELLS TO GERM CELLS,

出願番号:61/373,563,

発明者:斎藤通紀、林克彦,

発明の名称:METHOD OF INDUCING DIFFERENTIATION FROM PLURIPOTENT STEM CELLS TO GERM CELLS,

出願人:国立大学法人京都大学,

出願日:2010年8月13日

PLURIPOTENCY ASSOCIATED EPIGENETIC FACTOR (Attorney Docket No. 029240-9001-00)

出願番号: PCT/GB2009/050628,

発明者: Leng-Siew Yeap, Katsuhiko Hayashi, Azim Surani,

発明の名称: PLURIPOTENCY ASSOCIATED EPIGENETIC FACTOR (Attorney Docket No. 029240-9001-00),

出願人: Cambridge Enterprise Limited, 出願日: 4 June 2008

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